What is the diameter of the actin filament?

FEBS Letters

Grazi, Enrico¹ 

[1] Dipartimento di Biochimica e Biologia Molecolare, Università di Ferrara, Via Borsari 46, 44100 Ferrara, Italy

关键词: Cytosolic glutathione transferase;    Enzyme family;    Amino acid sequence;    Molecular evolution;    Structure–function relationship;   

DOI  :  10.1016/S0014-5793(97)00214-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The limits of the most recent models of the actin filament are discussed. These model are generated without taking into account the effect of protein osmotic pressure and, in general, of the solvent conditions. As a result they do not provide a bona fide representation of the actin filament in vivo. A new ‘fluttering wing’ model is proposed which predicts that orientation of the monomers, intermonomer contacts and diameter of the actin filament are sensitive to protein osmotic pressure and to interaction with regulatory proteins.

【 授权许可】

Unknown