FEBS Letters | |
H+‐proton‐pumping inorganic pyrophosphatase: a tightly membrane‐bound family | |
Baltscheffsky, Herrick1  Baltscheffsky, Margareta1  Schultz, Anders1  | |
[1] Department of Biochemistry, Arrhenius Laboratories, Stockholm University, S-106 91 Stockholm, Sweden | |
关键词: H+-proton-pumping inorganic pyrophosphatase; H+-proton-pumping inorganic pyrophosphate synthase; H+-ATPase; H+-ATP synthase; Amino acid sequence; Evolution; Enzyme family; PPi; inorganic pyrophosphate; PPase; inorganic pyrophosphatase; ATP; adenosine triphosphate; ATPase; adenosine triphosphatase; | |
DOI : 10.1016/S0014-5793(99)00617-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The earliest known H+-proton-pumping inorganic pyrophosphatase, the integrally membrane-bound H+-proton-pumping inorganic pyrophosphate synthase from Rhodospirillum rubrum, is still the only alternative to H+-ATP synthase in biological electron transport phosphorylation. Cloning of several higher plant vacuolar H+-proton-pumping inorganic pyrophosphatase genes has led to the recognition that the corresponding proteins form a family of extremely similar proton-pumping enzymes. The bacterial H+-proton-pumping inorganic pyrophosphate synthase and two algal vacuolar H+-proton-pumping inorganic pyrophosphatases are homologous with this family, as deduced from their cloned genes. The prokaryotic and algal homologues differ more than the H+-proton-pumping inorganic pyrophosphatases from higher plants, facilitating recognition of functionally significant entities. Primary structures of H+-proton-pumping inorganic pyrophosphatases are reviewed and compared with H+-ATPases and soluble proton-pumping inorganic pyrophosphatases.
【 授权许可】
Unknown
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