The glutamine ligand in the ferrous iron active site of isopenicillin N synthase of Streptomyces jumonjinensis is not essential for catalysis

FEBS Letters

Landman, Orna¹  Aharonowitz, Yair¹  Borovok, Ilya¹  Cohen, Gerald¹ 

[1] Department of Molecular Microbiology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat Aviv 69978, Israel

关键词: Isopenicillin N synthase;    Nonheme iron dioxygenase;    Protein ligand;    Mutagenesis;    ACV;    δ-(l-α-aminoadipoyl)-l-cysteinyl-d-valine;    IPNS;    isopenicillin N synthase;    ACCO;    1-aminocyclopropane-1-carboxylic acid oxidase;    SDS;    sodium dodecyl sulphate.;   

DOI  :  10.1016/S0014-5793(97)00180-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

© 1997 Federation of European Biochemical Societies.

【 授权许可】

Unknown