Hydrophobicity, hydrophobic moment and angle subtended by charged residues modulate antibacterial and haemolytic activity of amphipathic helical peptides

FEBS Letters

Beyermann, Michael¹  MacDonald, Dorothy L²  Wieprecht, Torsten¹  Dathe, Margitta¹  Maloy, W.Lee²  Nikolenko, Heike¹  Handel, Liselotte¹  Bienert, Michael¹ 

[1] Institute of Molecular Pharmacology, Alfred-Kowalke-Strasse 4, 10315 Berlin, Germany;Magainin Pharmaceuticals, Inc., 5110 Campus Drive, Plymouth Meeting, PA 19462, USA

关键词: Antimicrobial peptide;    Haemolysis;    Hydrophobicity;    Hydrophobic moment;    Magainin;   

DOI  :  10.1016/S0014-5793(97)00055-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

© Federation of European Biochemical Societies.

【 授权许可】

Unknown