Oxidation of N G‐hydroxyl‐l‐arginine to nitric oxide mediated by respiratory burst: an alternative pathway to NO synthesis

FEBS Letters

Eichmann, Klaus¹  Soler, Germán²  Modolell, Manuel¹ 

[1] Max-Planck-Institut für Immunbiologie, Stübeweg 51, 79108 Freiburg, Germany;Depto. de Bioquı́mica y Biologı́a Molecular, Facultad de Veterinaria, Universidad de Extremadura, Carretera de Trujillo s/n, 10071 Cáceres, Spain

关键词: Nitric oxide;    Superoxide anion;    Hydroxy-l-arginine;    Respiratory burst;    Phagocyte;    OH-Arg;    N G-hydroxy-l-arginine;    BMMΦ;    bone marrow-derived macrophages;    O− 2;    superoxide anion;   

DOI  :  10.1016/S0014-5793(96)01451-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

N ^G-Hydroxy-l-arginine is an intermediate metabolite in the synthesis of nitric oxide that is upregulated and secreted during acute inflammation in vivo. Previous reports have shown that chemically induced superoxide anion oxidizes N ^G-hydroxy-l-arginine to nitric oxide. Here, we demonstrate that this reaction takes place physiologically in phagocytic cells during the respiratory burst, and is independent of the presence of nitric oxide synthase.

【 授权许可】

Unknown