Expression of receptors for native and chemically modified low‐density lipoproteins in brain microvessels

FEBS Letters

Lucarelli, Marco²  Scarpa, Sigfrido²  Gennarelli, Massimo¹  Novelli, Giuseppe¹  Cardelli, Patrizia²  Dallapiccola, Bruno¹  Strom, Roberto² 

[1] Dept. of Public Health and Cellular Biology, University of Rome ‘Tor Vergata’, Via di Tor Vergata 135, 00133 Rome, Italy;Dept. of Human Biopathology, University of Rome ‘La Sapienza’, Viale Regina Elena 324, 00161 Rome, Italy

关键词: Scavenger receptor;    Low-density lipoprotein receptor;    Blood-brain barrier;    Chemically modified lipoprotein;    Cholesterol metabolism;    Atherosclerosis;    AcLDL;    acetylated low-density lipoprotein;    BBB;    blood-brain barrier;    CNS;    central nervous system;    Ecs;    endothelial cells;    LDL;    low-density lipoprotein;    LDL-R;    low-density lipoprotein receptor;    OxLDL;    oxidized low-density lipoprotein;    RT;    reverse transcriptase;    SCAV-R;    scavenger receptor;    SMCs;    smooth muscle cells;   

DOI  :  10.1016/S0014-5793(96)01435-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Despite the importance of cholesterol metabolism in the central nervous system, only relatively few studies have dealt with the cerebral uptake and transport of lipids into the brain compartment. These functions are mediated by the endothelium of brain microvessels, which forms the anatomical basis of the blood-brain barrier. By a reverse transcriptase PCR study of messenger RNA expression we could show, in bovine brain microvessels, the presence of transcripts of native low-density lipoprotein receptor and of both type I and II scavenger receptors. Brain microvessels therefore appear to play an active role in the uptake of native and modified low-density lipoproteins.

【 授权许可】

Unknown