The reaction mechanism of phosphomannomutase in plants

FEBS Letters

Oesterhelt, Christine¹  Schnarrenberger, Claus¹  Gross, Wolfgang¹ 

[1] Institut für Pflanzenphysiologie und Mikrobiologie, Freie Universität Berlin, Königin-Luise-Str. 12–16a, D-14195 Berlin, Germany

关键词: Galdieria sulphuraria;    Rhodophyta;    Phosphomannomutase;    Mannose-1;    6-bisphosphate;    Reaction mechanism;   

DOI  :  10.1016/S0014-5793(96)01425-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The enzyme phosphomannomutase catalyzes the interconversion of mannose-1-phosphate (Man-1-P) and mannose-6-phosphate (Man-6-P). In mammalian cells the enzyme has to be activated by transfer of a phosphate group from a sugar-1.6-P₂ (Guha, S.K. and Rose, Z.B. (1985) Arch. Biochem. Biophys. 243, 168). In contrast, in the red alga Galdieria sulphuraria the co-substrate (Man-1.6-P₂ or Glc-1.6-P₂) is converted to the corresponding sugar monophosphate while the substrate is converted to the sugar bisphosphate in each reaction cycle. Evidence is presented that the same reaction mechanism occurs in spinach and yeast.

【 授权许可】

Unknown