Lipobeads: a hydrogen anchored lipid vesicle system

FEBS Letters

Jin, T.¹  Lee, P.I.²  Pennefather, P.¹ 

[1] Faculty of Pharmacy, University of Toronto, 19 Russell St., Toronto, Ont., M5S 2S2, Canada;Schering-Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, NJ 07703-0539, USA

关键词: Supported lipid bilayer;    Hydrogel microsphere;    Polyvinyl alcohol;    Liposome;    Model membrane;    Artificial cell;   

DOI  :  10.1016/S0014-5793(96)01021-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new vesicle system is described that combines complementary properties of liposomes and polymeric beads. ‘Lipobeads’ consist of a lipid bilayer shell anchored on the surface of a hydrogel polymer cores which acts like a cytoskeleton. Anchoring is provided by fatty acids covalently attached to the surface of the hydrogel. These hydrophobic chains drive spontaneous assembly of a lipid bilayer shell around the modified hydrogel bead when exposed to a suspension of liposomes. The bilayer is stable and acts as a permeability barrier to compound loaded by prior absorption into the polymer core. Lipid mobility in the shell is similar to that found in other unanchored lipid bilayers. The system has potential application in drug delivery and for functional reconstitution of membrane proteins.

【 授权许可】

Unknown