The type‐1 repeats of thyroglobulin regulate thyroglobulin degradation and T3, T4 release in thyrocytes

FEBS Letters

Molina, Franck¹  Granier, Claude¹  Pau, Bernard¹ 

[1] CNRS UMR 9921 - Faculté de Pharmacie, Avenue Charles Flahault, 34000 Montpellier, France

关键词: Thyroglobulin;    Tg type-1 repeat;    Proteolysis;    Thyroid hormone release;    Module;   

DOI  :  10.1016/0014-5793(96)00708-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Thyroglobulin (Tg) proteolytic steps are central phenomena in Tg processing and thyroid hormone release in thyrocytes. Based on recent literature data, we propose that the type-1 repetitive units present in the Tg sequence could act as binders and reversible inhibitors of the proteases implicated in Tg processing. The pH-dependent interactions of proteases with the repeats could permit (i) protection from degradation of low iodinated Tg to be recycled; (ii) restriction of early proteolytic attacks to N- and C-terminal hormone formation sites; (iii) increase of the half-time of acidic proteases necessary for the final, extensive degradation steps of Tg.

【 授权许可】

Unknown