A fungal metabolite mediates degradation of non‐phenolic lignin structures and synthetic lignin by laccase

FEBS Letters

Eriksson, Karl-Erik L.¹  Eggert, Claudia¹  Temp, Ulrike¹  Dean, Jeffrey F.D.¹ 

[1] Department of Biochemistry and Molecular Biology, Center for Biological Resource Recovery, A 214 Life Science Building, University of Georgia, Athens, GA 30602-7229, USA

关键词: Lignin degradation;    White-rot;    Cinnabarinic acid;    3-Hydroxyanthranilate;    Redox mediator;    Pycnoporus cinnabarinus;    ABTS;    2;    2′-azino-bis-(3-ethylthiazoline-6-sulfonate);    3-HAA;    3-hydroxyanthranilate;    CA;    cinnabarinic acid;    DHP;    dehydropolymerizate;    LiP;    lignin peroxidase;    MnP;    manganese-dependent peroxidase;   

DOI  :  10.1016/0014-5793(96)00719-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lignin peroxidase is generally considered to be a primary catalyst for oxidative depolymerization of lignin by white-rot fungi. However, some white-rot fungi lack lignin peroxidase. Instead, many produce laccase, even though the redox potentials of known laccases are two to directly oxidize non-phenolic components of lignin. Pycnoporus cinnabarinus is one example of a laccase-producing fungus that degrades lignin very efficiently. To overcome the redox potential barrier, P. cinnabarinus produces a metabolite, 3-hydroxyanthranilate that can mediate the oxidation of non-phenolic substrates by laccase. This is the first description of how laccase might function in a biological system for the complete depolymerization of lignin.

【 授权许可】

Unknown