A novel murine cathelin‐like protein expressed in bone marrow

FEBS Letters

Popsueva, Anna E.¹  Zinovjeva, Marina V.¹  Belyavsky, Alexander V.¹  Zijlmans, J.Mark J.M.³  Fibbe, Willem E.³  Visser, Jan W.M.² 

[1] Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, 117984 Moscow B-334, Russian Federation;New York Blood Center, 310 East 67th Str., New York, NY, USA;Department of Hematology, University Medical Center, Rijnsburgerweg 10, Leiden, The Netherlands

关键词: Antibacterial protein;    Amphipathic α-helix;    Hematopoietic stem/progenitor cells;    cDNA;    Cathelin;   

DOI  :  10.1016/0014-5793(96)00692-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A novel cDNA encoding a putative secreted protein was isolated from murine bone marrow. The encoded protein named MCLP (urine athelin-ike rotein) was found to be highly homologous to the pig cathelin, and to four neutrophil antimicrobial polypeptides: CAP 18, indolicidin, Bac 5 and FALL-39. Secondary structure prediction studies identified a highly cationic region in the C-terminal part of prepro-MCLP with a tendency to adopt an amphipathic α-helical conformation, as observed in many antimicrobial peptides. However, no antibacterial activity was observed with the synthetic peptide corresponding to this region of MCLP.

【 授权许可】

Unknown