Two myogenic regulatory factor transcripts exhibit muscle‐specific responses to disuse and passive stretch in adult rats

FEBS Letters

Brownson, Carol¹  Loughna, Paul T.² 

[1] School of Life Sciences, University of North London, London N7 8DB, UK;Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, LondoN NW1 0TU, UK

关键词: Stretch;    Disuse;    Immobilisation;    Myogenin;    MRF4;   

DOI  :  10.1016/0014-5793(96)00681-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Levels of myogenic regulatory factor (MRF) transcripts are altered in a muscle-specific manner in response to hind limb immobilisation of adult male rats, for a 2 day period, in either a lengthened or shortened position which result in passive stretch or disuse atrophy respectively. Myogenin transcript levels were dramatically elevated in the stretched plantaris but not soleus, whereas the MRF4 transcript was significantly elevated in soleus but not plantaris. Levels of myogenin mRNA were unaffected by disuse in either muscle and MRF4 was markedly lower in plantaris in response to disuse.

【 授权许可】

Unknown