The putatively protective Onchocerca volvulus neuronal protein E1 is a member of the death domain protein family

FEBS Letters

Domeyer, A.¹  Erttmann, K.D.¹  Gallin, M.¹ 

[1] Section of Molecular Biology, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany

关键词: Helminth;    Parasite;    Ankyrin;    Apoptosis;    Neuronal protein;    Onchocerca volvulus;    DD;    death domain;    p55 TNF-R;    the p55 tumor necrosis factor receptor;    NGF-R;    nerve growth factor receptor;    unc-44 gene;    ankyrin-related gene of Caenorhabditis elegans;   

DOI  :  10.1016/0014-5793(96)00620-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Here we show that E1, an ankyrin-related, potentially protective, neuronal protein of the human filarial nematode Onchocerca volvulus contains a death domain (DD), most similar to that of human Mort1/FADD (39% identity). In addition, sequence comparison of E1 to its homologue from Litomosoides sigmodontis and to Caenorhabditis elegans ankyrin defines two further putative functional domains. One represents the end of the spectrin-binding domain of ankyrins, the other an unique domain, most highly conserved between these nematodes, containing a calpain sequence motif. Thus, E1 may be involved in apoptosis, raising the possibility that protection against this parasitic helminth may be induced by apoptotic processes.

【 授权许可】

Unknown