Palmitoylcarnitine, a surface‐active metabolite

FEBS Letters

Alonso, Alicia¹  Goñi, Félix M.¹  Requero, M.Asun¹ 

[1] Grupo Biomembranas (Unidad Asociada al CSIC), Departamento de Bioquímica, Universidad del Pais Vasco, Aptdo. 644, 48080 Bilbao, Spain

关键词: Carnitine;    Membrane leakage;    Membrane solubilization;    Mitochondrial fatty acid oxidation;    Carnitine palmitoyl transferase;    Myocardial ischemia;    CoA;    coenzyme A;    cmc;    critical micellar concentration;    Re;    effective surfactant/lipid molar ratio;   

DOI  :  10.1016/0014-5793(96)00603-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Palmitoylcarnitine is a well-known intermediate in mitochondrial fatty acid oxidation. Less known are its properties as a surfactant, with a capacity to solubilize biological membranes similar to that of many synthetic detergents used in the biochemical laboratory. Some of the physico-chemical properties of palmitoylcarnitine may help to explain the need for coenzyme A-carnitine-coenzyme A acyl exchange during mitochondrial fatty acid import. The amphiphilic character of palmitoylcarnitine may also explain its proposed involvement in the pathogenesis of myocardial ischemia.

【 授权许可】

Unknown