Sequencing and functional analysis of the genome of Bacillus subtilis strain 168

FEBS Letters

Wipat, Anil¹  Harwood, Colin R.¹ 

[1] DApartment of Microbiology, School of Microbiological, Immunological and Virological Sciences, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK

关键词: Genome sequencing;    Gene function;    Gram-positive bacteria;    Yeast artificial chromosome;    Chromosome walking;    Integrational vector;   

DOI  :  10.1016/0014-5793(96)00524-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The international programme to sequence the 4.2 Mb genome of Bacillus subtilis, a model Gram-positive bacterium, is a joint project involving European, Japanese and US research groups. To date ca. 3.0 Mb of the genome has been sequenced, with the remaining 1.2 Mb expected to be completed in 1997. The amenability of B. subtilis to genetic manipulation, combined with the availability of extensive expertise on its biochemistry and physiology, makes this bacterium a valuable organism in which to investigate the properties of genes for which functions cannot be readily ascribed by standard methods.

【 授权许可】

Unknown