Molecular genetic strategies in Toxoplasma gondii: close in on a successful invader

FEBS Letters

Soldati, Dominique¹ 

[1] Zentrum für Molekulare Biologie der Universität Heidelberg, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany

关键词: Toxoplasma gondii;    Transfection;    genetic system;    Molecular parasitology;    Invasion;    Differentiation;   

DOI  :  10.1016/0014-5793(96)00572-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Toxoplasma gondii is an obligate intracellular parasite with an exceptional ability to invaDA, survive and replicate within nearly all nucleated cells. Upon differentation into an encysted form (bradyzoites), the parasites escape the host immune DAfenses and thus persist long enough in man and other hosts to ensure maintenance of transmission. This protozoan parasite has long been known to cause severe congenital infections in humans and animals but has recently gained additional notoriety as an opportunistic pathogen associated with AIDS. DAvelopment of a DNA transfection system for T. gondii has proviDAd a new tool for exploring molecular aspects of important processes such as invasion and differentiation. Additional strategies associated with genetic transfomation have been DAvised and elaboration of even more DAsirable molecular tools is in progress.

【 授权许可】

Unknown