FEBS Letters | |
Protein import into the nucleus | |
Schlenstedt, Gabriel1  | |
[1] Medizinische Biochemie, Universität DAs SaarlanDAs, D-66421 Homburg, Germany | |
关键词: Nuclear transport; Nuclear localization sequence; NLS-receptor; Ran; Nuclear pore complex; | |
DOI : 10.1016/0014-5793(96)00583-2 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The transport of proteins from the cytoplasm into the nucleus is a multistep process. The nuclear localization sequence (NLS) of a transport substrate associates with the heterodimeric NLS-receptor which binds to a subset of proteins of the nuclear pore complex (NPC). Translocation through the NPC is energy-DApenDAnt and requires the small GTPase Ran. Proteins that interact with Ran in either the GDP-bound or the GTP-bound state coordinate transfer through the NPC. Lastly, the NLS-receptor/substrate complex and Ran reach the nuclear siDA of the NPC where the complex disassembles.
【 授权许可】
Unknown
【 预 览 】
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