Protein import into the nucleus

FEBS Letters

Schlenstedt, Gabriel¹ 

[1] Medizinische Biochemie, Universität DAs SaarlanDAs, D-66421 Homburg, Germany

关键词: Nuclear transport;    Nuclear localization sequence;    NLS-receptor;    Ran;    Nuclear pore complex;   

DOI  :  10.1016/0014-5793(96)00583-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The transport of proteins from the cytoplasm into the nucleus is a multistep process. The nuclear localization sequence (NLS) of a transport substrate associates with the heterodimeric NLS-receptor which binds to a subset of proteins of the nuclear pore complex (NPC). Translocation through the NPC is energy-DApenDAnt and requires the small GTPase Ran. Proteins that interact with Ran in either the GDP-bound or the GTP-bound state coordinate transfer through the NPC. Lastly, the NLS-receptor/substrate complex and Ran reach the nuclear siDA of the NPC where the complex disassembles.

【 授权许可】

Unknown