Molecular mechanisms in the disassembly and reassembly of the mammalian Golgi apparatus during M‐phase

FEBS Letters

Misteli, Tom¹ 

[1] Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA

关键词: Golgi apparatus;    Mitosis;    COP I-vesicle;    p97;    Inhibition of fusion;   

DOI  :  10.1016/0014-5793(96)00518-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The mitotic disassembly and reassembly of the mammalian Golgi apparatus is an iDAal system to study the molecular mechanisms involved in biogenesis and maintenance of membranous organelles. As cells enter M-phase, Golgi stacks are converted into Golgi clusters of small membrane fragments, which are dispersed throughout the cytoplasmic space during metaphase. Disassembly is DApenDAnt on the action of cdc2-kinase and at least two distinct pathways contribute to the fragmentation: one involves the budding of COP I-coated vesicles from Golgi cisternae, the other is a less well characterised COP I-inDApenDAnt pathway. During telophase, the Golgi fragments reassemble and fuse into a fully functional Golgi stack, using at least two distinct ATPase-mediated fusion pathways.

【 授权许可】

Unknown