Effects of phorbol esters on insulin‐induced activation of phosphatidylinositol 3‐kinase, glucose transport, and glycogen synthase in rat adipocytes

FEBS Letters

Bandyopadhyay, G.¹  Farese, R.V.¹  Galloway, L.¹  Standaert, M.L.¹ 

[1] Research Service (VAR 151), J.A. Haley Veterans' Hospital; Departments of Internal Medicine and Biochemistry, University of South Florida College of Medicine, University of South Florida, 13000 Bruce Downs Blvd., Tampa, FL 33612, USA

关键词: Insulin;    Phorbol ester;    Phosphatidylinositol 3-kinase;    Glucose transport;    Adipocyte;    IRS-1;   

DOI  :  10.1016/0014-5793(96)00492-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In rat adipocytes, phorbol ester-induced activation of PKC did not inhibit insulin signalling through IRS-1-dependent phosphatidylinositol (PI) 3-kinase activation. Moreover, phorbol esters alone provoked an increase in membrane PI 3-kinase activity. These findings may be relevant to the failure of phorbol esters to inhibit insulin effects on glucose transport and glycogen synthesis in rat adipocytes.

【 授权许可】

Unknown