Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats

FEBS Letters

Dietmeier, Klaus¹  Pfanner, Nikolaus¹  Bömer, Ulf¹ 

[1] Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Straβe 7, D-79104 Freiburg, Germany

关键词: Mitochondria;    Translocase of outer mitochondrial membrane;    Protein sorting;    Import receptor;    Tom;    translocase of outer mitochondrial membrane (new uniform nomenclature [4]);    Tom70 was formerly termed Mas70 or Mom72;    Tom40 was termed Isp42 or Mom38;    Tom20 was termed Mas20 or Mom19;    TPR;    tetratrico peptide repeat;   

DOI  :  10.1016/0014-5793(96)00156-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The mitochondrial outer membrane contains a protein complex with at least eight subunits responsible for recognition and translocation of preproteins synthesized in the cytosol. Two subunits, the receptors Tom20 and Tom70, contain tetratrico peptide repeats that are thought to be involved in protein-protein interactions. We have identified Saccharomyces cerevisiae Tom72, a new Tom protein expressed at a low level. Tom72 is homologous to Tom70, including seven tetratrico peptide repeats. Tom72 is targeted to the mitochondrial outer membrane, forms a large domain exposed to the cytosol and loosely associates with the translocase complex of the outer membrane. These results suggest that Tom72 represents a ninth, weakly expressed component of the preprotein translocase of the mitochondrial outer membrane.

【 授权许可】

Unknown