The SV40 T‐antigen induces premature apoptotic mammary gland involution during late pregnancy in transgenic mice

FEBS Letters

Graessmann, A.¹  Santarelli, R.¹  Gottlob, K.¹  Tzeng, Y.J.¹ 

[1] Institut für Molekularbiologie und Biochemie der Freien Universität Berlin, Arnimallee 22, 14195 Berlin, Germany

关键词: SV40 T-antigen;    Transgenic animal;    Mammary gland;    Premature apoptosis;    Breast cancer;   

DOI  :  10.1016/0014-5793(96)00021-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transgenic animals of the line 8 contain the WAP-SV-T transgene. Females of this line synthesise the SV40 T-antigen in mammary gland epithelial cells during pregnancy and the lactation period. All females are ‘milk-less’ and the offspring have to be nursed by foster mothers. The reason for this phenomenon is a premature apoptosis during late pregnancy. Nonetheless a significant number of mammary epithelial cells escape apoptosis and all transgenic females develop breast cancer after the first lactation period.

【 授权许可】

Unknown