SnoRNA U21 is also intron‐encoded in Drosophila melanogaster but in a different host‐gene as compared to warm‐blooded vertebrates

FEBS Letters

Qu, Liang-Hu¹  Nicoloso, Monique¹  Bachellerie, Jean-Pierre¹  Renalier, Marie-Hélène¹ 

[1] Laboratorie de Biologie Moléculaire Eucaryote du CNRS, Université Paul-Sabatier, 118 Route de Narbonne, 31062 Toulouse Cédex, France

关键词: snoRNA;    Intron;    U21;    rRNA processing;    ARF 1 gene;    Drosophila;   

DOI  :  10.1016/0014-5793(95)01511-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

U21 is an intron-encoded snoRNA in vertebrates which contains a 13-nt tract of complementarity to an invariant sequence in eukaryotic 28S rRNA. Here, we report the characterization of its Drosophila melanogaster homolog which is the first case of an intron-encoded snoRNA in an invertebrate metazoan. In D. melanogaster, U21 is encoded within the ARF-1 (ADP ribosylation factor 1) gene, whereas in chicken and mammals it is found in the ribosomal protein L5 gene. In D. melanogaster, like in vertebrates, U21 is devoid of a 5′ trimethylguanosine cap, thus, likely resulting from processing of intronic RNA. The only portion of U21 sequence preserved between D. melanogaster and vertebrates, in addition to the hallmark box C and box D motifs, corresponds precisely to the 13-nt complementary to rRNA, pointing to an important role of the pairing of U21 to pre-rRNA.

【 授权许可】

Unknown