Role of multiple cellular proteases in the execution of programmed cell death

FEBS Letters

Kumar, Sharad¹  Harvey, Natasha L¹ 

[1] The Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Box 14, Rundle Mall Post Office, Adelaide, SA 5000, Australia

关键词: Apoptosis;    Cysteine proteases;    Interleukin-1β converting enzyme;    Nedd2/Ich-1;    prICE/CPP32/Yama/ apopain;    TX/ICErelII/Ich-2;    ICErelIII;    Mch2;    ICE;    interleukin-1β converting enzyme;    TPCK;    N-tosyl-l-phenylalanine chloromethyl ketone;    DCI;    3;    4-dichloroisocoumarin;    TLCK N-tosyl-l-lysyl chloromethyl ketone;    TAME;    N-tosyl-l-arginine methyl ester;    YVAD-CMK;    Tyr-Val-Ala-Asp-chrolomethyl ketone;    PARP;    poly(ADP-ribose) polymerase;    IL-1β;    interleukin-1β;    pIL-1β;    pro-IL-1β;   

DOI  :  10.1016/0014-5793(95)01186-I

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A family of mammalian homologues of the Caenorhabditis elegans cell death protein Ced-3 has been recently discovered. These mammalian proteins encode novel cysteine proteases with homology to the interleukin-1β converting enzyme (ICE). Although several studies support a role for one or more of these proteases in mediating apoptosis, their mechanism of action is far from understood. The presence of multiple mammalian ICE-like proteases, with apparently similar apoptotic function indicates that, despite its conservation during evolution, the cell death pathway is much more complex in mammals than in the worm. In addition to ICE-like proteases, several other proteases of different cleavage specificities have been implicated in apoptosis. There is now a growing body of evidence suggesting that apoptosis involves the activation of a cascade of proteases. This article summarises the presently available evidence and discusses how multiple proteases might be required in the effector phase of cell death.

【 授权许可】

Unknown