Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin

FEBS Letters

Mihm, M.³  Ermak, G.³  Mazurkiewicz, J.E.¹  Slominski, A.³  Chakraborty, A.²  Hwang, J.³ 

[1] Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, Albany, NY 12208, USA;Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA;Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY 12208, USA

关键词: POM;    Corticotropin releasing hormone (CRH);    Corticotropin releasing hormone receptor;    Hypothalamus-pituitary axis;    Melanocyte;    Keratinocyte;   

DOI  :  10.1016/0014-5793(95)01090-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Evidence is provided that human skin, the largest body organ exposed to multiple stressors, expresses proopiomelanocortin (POMC), corticotropin releasing hormone (CRH) and CRH-receptor (CRHR) genes in vivo. In vitro studies show that POMC and CRHR mRNAs are transcribed in melanocytes, cells derived from the neural crest, and in keratinocytes, cells derived from the ectoderm. CRH mRNA is transcribed in cultured melanocytes but not in keratinocytes. It is proposed that an equivalent of the ‘hypothalamus-pituitary axis’ composed of the CRH-CRHR-POMC loop is conserved in mammalian skin.

【 授权许可】

Unknown