Regulation of intracellular pH by cell‐cell adhesive interactions

FEBS Letters

Sud'ina, G.F.¹  Dergacheva, G.B.¹  Galkina, S.I.¹  Margolis, L.B.¹ 

[1] A.N. Belozersky Institute of Physico-Chemical Biology of Moscow State University, Moscow 119899, Russian Federation

关键词: Intracellular pH;    Cell-cell interaction;    Phospholipase A2;    Protein kinase C;    H+-ATPase;    Na+/H+ antiporter;    H+-conductance;    PLA2;    phospholipase A2;    PLC;    phospholipase C;    PKC;    protein kinase C;    Cl-NBD;    7-chloro-4-nitrobenz-2-oxa-1;    3-diazole;    NEM;    N-ethylmaleimide;   

DOI  :  10.1016/0014-5793(95)00969-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Inhibitors of phospholipase A₂ (4-bromophenacyl-bromide), phospholipase C (neomycin) and protein kinase C (H-7) dramatically change the way the pH_i is modulated by local cell density. It is suggested that cell-cell interactions regulate cell activities via modulation of pH_i, which is under positive control from phospholipase A2 and under negative control from protein kinase C.

【 授权许可】

Unknown