The features of the spatial structure of the gramicidine A‐cesium complex

FEBS Letters

Timofeev, Vladimir P.¹  Nekrasov, Alexei N.¹  Stepanov, Anatoly V.² 

[1] Engelhardt Institute of Molecular Biology, 117946 Moscow, ul. Vavilova, 32, Russian Federation;Byelorussian State University, 20064 Minsk, ul. Kurchatova, 7, 807B Byelorussia

关键词: Gramicidine A;    Ion channel;    1H NMR;    Conformational mobility;   

DOI  :  10.1016/0014-5793(95)00800-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Earlier obtained two-dimensional ¹H-NMR spectroscopy data were used to analyze the spatial structure and conformational mobility of the double right ↑↓ ππ _LD ^7.2 helix of the complex formed by gramicidine A and Cs⁺ ions in an organic solvent (a chloroform-methanol mixture). Analysis of the experimental data permitted the determination of a set of conformations for each of the high-mobility residue side chains in the solution. The energy refinement of the most probable conformation of the double right ↑↓ ππ _LD ^7.2 helix was made and conformational rearrangements of the tryptophan residue side chain were studied in detail.

【 授权许可】

Unknown