Identification of a member of mouse semaphorin family

FEBS Letters

关键词: Semaphorin;    Collapsin;    Axon guidance;    Cloning;    Transmembrane;    Mouse;    Sema I–III;    semaphorin I–III;    Fas IV;    fasciclin IV;   

DOI  :  10.1016/0014-5793(95)00850-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Grasshopper semaphorin I (Sema I) and its related proteins, chick collapsin and mouse Sema III contribute to the axon guidance by their repellent actions [5,9,12]. We have identified a member of semaphorin gene family from the mouse brain and named it M-Sema F. The N-terminal encodes a semaphorin domain that is similar between Sema I–III [6] followed by a single putative immunoglobulin-like domain, a transmembrane domain, and a proline-rich intracellular domain. M-Sema F mRNA is expressed widely in the nervous tissues during development. These suggest that M-Sema F is a transmembrane member of the semaphorin family of the vertebrate which may function in the developing neuronal network.

【 授权许可】

Unknown