期刊论文详细信息
FEBS Letters | |
Influence of synthetic peptides, corresponding to fragments of the human α‐2 interferon molecule, on the proliferation of lymphoblastoid cells in vitro. Growth inhibition and receptor binding | |
Makarov, E.2  Makarova, N.1  Kushch, A.1  Romashkova, J.3  Danilkovich, A.3  Targoni, O.3  Freze, K.3  Valujskikh, A.3  | |
[1] D.I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow, Russian Federation;Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation;Department of Cellular and Immunology, Biological Faculty, Moscow State University, Moscow, Russian Federation | |
关键词: Synthetic peptide; Interferon α; Tumor cell; Growth inhibition; Receptor; IFN; interferon; [3H]TdR; [3H]thymidine; K d; equilibrium dissociation constant; IC50; concentration of competing ligand causing half-maximum displacement; K i; inhibition constant; | |
DOI : 10.1016/0014-5793(95)00731-N | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
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【 摘 要 】
Influence of nine synthetic peptides from the C-terminal part of human α-2 interferon (EN) molecule on growth of a human T-lymphoblastoid cell line MT-4 was investigated. It was shown that some peptides inhibited the proliferation of MT-4 cells. It was also found that MT-4 cells expressed specific receptors on the outer surface of the plasma membrane. All studied peptides competed for binding to a common binding site. Antiproliferative activity of the peptides correlated with their length and affinity to receptors on the outer membrane of MT-4 cells.
【 授权许可】
Unknown
【 预 览 】
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RO201912020301442ZK.pdf | 283KB | ![]() |