Growth factor‐induced release of a glycosyl‐phosphatidylinositol (GPI)‐linked protein from the HEp‐2 human carcinoma cell line

FEBS Letters

Roberts, Julia M.¹  Johnson, Peter M.¹  Kenton, Paul¹ 

[1] Department of Immunology, University of Liverpool, Liverpool, UK

关键词: GPI-linked protein;    Placental type alkaline phosphatase;    Growth factor;    Tumor cell;   

DOI  :  10.1016/0014-5793(90)80927-B

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The release of a GPI-linked oncofetal protein (PLAP) from HEp-2 cells has been studied as an indicator of endogenous PI-specific PLC activation. A non-hydrolysable GTP analogue, EGF and insulin all produced a dose-dependent release of PLAP from these cells. This indicates that an increase in PLC activity following either growth factor binding or G protein activation may cause cellular release of PLAP.

【 授权许可】

Unknown