Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

FEBS Letters

Brown, Guy C.¹ 

[1] Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK

关键词: Nitric oxide;    Cytochrome c oxidase;    Mitochondria;    Oxygen sensor;    Muscle relaxation;    Cytokines;   

DOI  :  10.1016/0014-5793(95)00763-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at cytochrome oxidase. Concentrations of NO measured in a range of biological systems are similar to those shown to inhibit cytochrome oxidase and mitochondrial respiration. Inhibition of NO synthesis results in a stimulation of respiration in a number of systems. It is proposed that NO exerts some of its main physiological and pathological effects on cell functions by inhibiting cytochrome oxidase. Further NO may be a physiological regulator of the affinity of mitochondrial respiration for oxygen, enabling mitochondria to act as sensors of oxygen over the physiological range.

【 授权许可】

Unknown