Identification of additional homologues of subunits VII and VIII of the ubiquinol‐cytochrome c oxidoreductase enables definition of consensus sequences

FEBS Letters

Grivell, Leslie A.¹  Berden, Jan A.²  Boumans, Hans² 

[1] Department of Molecular Cell Biology, Section for Molecular Biology, University of Amsterdam, Amsterdam, The Netherlands;E.C. Slater Institute, University of Amsterdam, Plantage Muidergracht 12, Amsterdam 1018 TV, The Netherlands

关键词: Ubiquinol-cytochrome c oxidoreductase;    Multiple sequence alignment;    Consensus sequence;    Candida utilis;   

DOI  :  10.1016/0014-5793(95)00611-C

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Candida utilis QCR7 gene encoding subunit VII of the ubiquinol-cytochrome c oxidoreductase was isolated by functional complementation of the Saccharomyces cerevisiae subunit VII-null mutant. Several other subunit VII homologues as well as homologues for subunit VIII were identified by screening the GenBank database. Some of these homologues for subunit VII could only be identified as such using a consensus sequence that was derived from the multiple sequence alignment. Definition of the consensus should facilitate further analysis of structure/function relationships in this protein.

【 授权许可】

Unknown