Human prothymosin α inhibits division of yeast Saccharomyces cerevisiae cells, while its mutant lacking nuclear localization signal does not

FEBS Letters

Pavlov, Nickolay¹  Evstafieva, Alexandra¹  Rubtsov, Yury¹  Vartapetian, Andrey¹ 

[1] Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119899 Moscow, Russian Federation

关键词: Prothymosin α;    Cell division;    Nuclear localization signal;    S. cerevisiae;    PCR;    polymerase chain reaction;    ProTα;    prothymosin a;   

DOI  :  10.1016/0014-5793(95)00483-P

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Effect of human prothymosin α and its mutant over-produced in S. cerevisiae on yeast cell division was studied. Wild-type prothymosin α appeared to block division of yeast cells. Its inhibitory action could be abolished by deletion of the last nine carboxy-terminal amino acids of prothymosin α containing nuclear localization signal, thus pointing to the nucleus as a compartment, where prothymosin α performs its action.

【 授权许可】

Unknown