Strand scission in DNA induced by l‐DOPA in the presence of Cu(II)

FEBS Letters

Hadi, S.M.¹  Husain, Seema¹ 

[1] Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh-202 002, India

关键词: DNA Cleavage;    l-DOPA;    Copper;    Reactive oxygen species;   

DOI  :  10.1016/0014-5793(95)00365-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It has been recently reported that l-DOPA and Cu(II) in the presence of H₂O₂ leads to extensive DNA damage. In this paper we show that l-DOPA in the presence of Cu(II) alone can cause DNA cleavage through the generation of reactive oxygen species such as the hydroxyl radical. Fluorescence quenching studies indicate that l-DOPA is capable of binding to DNA.

【 授权许可】

Unknown