Superoxide dismutase and glutathione peroxidase activities are increased by enalapril and captopril in mouse liver

FEBS Letters

de Cavanagh, Elena M.V.¹  Ercole, Liliana¹  Inserra, Felipe¹  Fraga, César G.²  Ferder, León¹  Romano, Luis¹ 

[1] Institute of Nephrology, Jewish Hospital, Buenos Aires, Argentina;Physical Chemistry Division, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina

关键词: Oxygen radical;    Enalapril;    Captopril;    Antioxidant;    Aging;    Hypertension;   

DOI  :  10.1016/0014-5793(95)00137-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have characterized the effect of angiotensin converting enzyme (ACE) inhibitors on the activity of CuZn-superoxide dismutase (CuZn-SOD), Mn-superoxide dismutase (Mn-SOD), catalase, and selenium-dependent glutathione peroxidase (Se-GPx). CF1 mice (4-month-old females) were administered water containing enalapril (20 mg/l) or captopril (50 mg/l), during 4 to 11 weeks. After 11 weeks, enalapril treatment caused an increase in the activity of CuZn-SOD, Mn-SOD and Se-GPx, from 19 ± 4 to 46 ± 7, 2.1 ± 0.2 to 3.8 ± 0.2 units/mg protein and 27 ± 3 to 54 ± 3 milliunits/mg protein, respectively. After 11 weeks, captopril treatment increased the activities (P < 0.05) of CuZn-SOD, MnSOD and Se-GPx to 35 ± 4, 2.9 ± 0.2 units/mg protein, and 38 ± 2 milliunits/mg protein, respectively. Catalase activity was not affected by the treatments. These results suggest that ACE inhibitors may protect cell components from oxidative damage by increasing the enzymatic antioxidant defenses.

【 授权许可】

Unknown