Molecular evolution of receptors for eicosanoids

FEBS Letters

Toh, Hiroyuki²  Ichikawa, Atsushi³  Narumiya, Shuh¹ 

[1]Department of Pharmacology, Faculty of Medicine, Kyoto University, Sakyo-Ku, Kyoto 606, Japan

[2]Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, Iizuka, Fukuoka 820, Japan

[3]Department of Physiological Chemistry, Faculty of Pharmaceutal Sciences, Kyoto University, Sakyo-Ku, Kyoto 606, Japan

关键词: Eicosanoids receptor;    Rhodopsin family;    Phylogenetic tree;    TX;    thromboxane;    PG;    prostaglandin;    LX;    lipoxin;    TXA;    thromboxane A2;    PGD;    prostaglandin D2;    PGE;    prostaglandin E2;    PGF;    prostaglandin F2α;    PGI;    prostacyclin;    LXA;    lipoxin A4;    PAF;    platelet-activating factor;   

DOI  :  10.1016/0014-5793(95)00129-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The amino acid sequences of the receptors for various prostaglandins, thromboxane and lipoxin, which belong to the rhodopsin family, were aligned, and a phylogenetic tree was constructed to infer the evolutionary history of the arachidonic acid cascade. The obtained tree suggested that the origin of the cyclooxygenase pathway was different from that of the lipoxygenase pathway. The receptors involved in the cyclooxygenase pathway constructed an independent cluster, but the lipoxin A₄ receptor, which is involved in the lipoxygenase pathway, belonged to the cluster of peptide receptors. The primitive form of the cyclooxygenase pathway had been a signal transduction system composed of prostaglandin E₂ and its receptor associated with cAMP metabolism.

【 授权许可】

Unknown