A yellow component associated with human transthyretin has properties like a pterin derivative, 7,8‐dihydropterin‐6‐carboxaldehyde

FEBS Letters

Pettersson, Tom³  Ernström, Ulf¹  Jörnvall, Hans² 

[1] Department of Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden;Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden;Department of Clinical Chemistry, Karolinska Institutet, Danderyd Hospital, S-182 88 Danderyd, Sweden

关键词: Transthyretin;    Prealbumin;    Carrier protein;    Pterin;    Folate;    Thyroxine;    Human;   

DOI  :  10.1016/0014-5793(95)00095-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transthyretin (TTR) in plasma is associated with yellow compounds. Their properties differ, and in the chicken protein a major yellow compound has recently been identified as a carotenoid, lutein, also called xanthophyll. We now show that the major yellow component extracted from human TTR has properties like a pterin derivative, 7,8-dihydropterin-6-carboxyaldehyde (2-amino-4-hydroxy-6-formyl-7,8-dihydropteridine). The human TTR derivative has chromatographic and spectral properties identical to a yellow photochemical degradation product of biopterin and a spectrum like that of the pterin aldehyde.

【 授权许可】

Unknown