The non‐steroidal anti‐inflammatory drug, indomethacin, as an inhibitor of HIV replication

FEBS Letters

Bourinbaiar, Aldar S.¹  Lee-Huang, Sylvia¹ 

[1] Department of Biochemistry, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA

关键词: AIDS;    HIV;    Indomethacin;    Lymphocyte;    Membrane lipid;    Prostaglandin;    AIDS;    acquired immunodeficiency syndrome;    CH;    cholesterol;    CO;    cyclooxygenase;    HIV;    human immunodeficiency virus;    LP;    5-lipoxygenase;    NGDA;    nordihydroguaiaretic acid;    PG;    prostaglandin;    PL;    phospholipid;   

DOI  :  10.1016/0014-5793(95)00057-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Indomethacin, a common non-steroidal anti-inflammatory drug (NSAID), has been used to treat rheumatoid arthritis. Although indomethacin has also been used as an immunopotentiator and symptomatic NSAID in AIDS, its effect on HIV replication is unknown. MT-4 lymphocytes were inoculated with HIV in the presence of indomethacin and tested for p24 expression by ELISA. The 50% inhibition (IC₅₀) was 10 μM, corresponding to plasma levels after administration of 50 mg oral indomethacin. The antiviral effect appears to be specific since no toxicity has been observed at the IC₅₀ dose, and unrelated NSAIDs have not shown the activity at clinical doses. Indomethacin may, thus, represent a new class of anti-HIV drug.

【 授权许可】

Unknown