Inhibitory effect of human chorionic gonadotropin (hCG) on HIV‐1 transmission from lymphocytes to trophoblasts

FEBS Letters

Bourinbaiar, Aldar S.²  Nagorny, Raisa¹ 

[1] The Population Council, Center for Biomedical Research, 1230 York Avenue, New York, NY 10021, USA;118 East 10th Street, New York, NY 10003, USA

关键词: hCG;    HIV;    Lymphocyte;    Trophoblast;    Placenta;   

DOI  :  10.1016/0014-5793(92)80744-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It has been demonstrated that human chorionic gonadotropin (hCG) inhibits HIV production in vitro, suggesting that this soluble placental glycoprotein can control viral replication and spread in vivo, hCG - the major product of fetal trophoblasts - was tested on an in vitro model consisting of choriocarcinoma-derived ENAMI trophoblasts exposed to HIV-infected MOLT-4 lymphocytes. The results show a U-shaped antiviral dose- effect and suggest that hCG may contribute to protection against intrauterine transmission of HIV-1.

【 授权许可】

Unknown