期刊论文详细信息
FEBS Letters
Chaos in DNA partition during the last mitoses of the proliferative life‐span of human fibroblasts
Macieira-Coelho, A.1 
[1] INSERM and University of Paris VI, 73 bis rue Maréchal Foch, 78000 Versailles, France
关键词: Human fibroblast;    Aging;    Senescence;    Terminal differentiation;    Quantal mitosis;   
DOI  :  10.1016/0014-5793(94)01407-R
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

We have followed with autoradiography the course of DNA synthesis and with cytofluorometry the partition of DNA during mitosis, through the different phases of the life-span of human fibroblasts. Towards the end of the proliferative potential of the cell population, DNA synthesis was disturbed during the late part of the S period. The DNA content of metaphases and of anaphases had a normal Gaussian distribution during the whole proliferative life-span of the cell population. At the very end, however, when cells entered the post-mitotic phase, the distribution of DNA content deviated from the normal Gaussian probability, becoming significantly skewed.

【 授权许可】

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