FEBS Letters | |
Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse Islets of Langerhans | |
Benig, Michelle1  Steiner, Donald F.1  Carroll, Raymond1  Martin, Sean K.1  | |
[1] Department of Biochemistry and Molecular Biology, The University of Chicago, and The Howard Hughes Medical Institute, 5841 S. Maryland Avenue, Chicago, IL 60637, USA | |
关键词: Prohormone convertase; β-Cell; Translational control; Precursor processing; | |
DOI : 10.1016/0014-5793(94)01284-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The prohormone convertases PC2 and PC3 have been shown to catalyze the processing of proinsulin to insulin in pancreatic β-cells. In these studies we have compared the effects of glucose on PC2 and PC3 biosynthesis in freshly isolated islets from normal and hyperglycemic (ob/ob) mice. In contrast to normal islets [Alarcón, et al. (1993) J. Biol. Chem. 268, 4276] the biosynthesis of both PC2 and PC3 is stimulated by glucose, parallel to the stimulation of proinsulin in the (ob/ob) islets. Inhibition of PC2 biosynthesis by glucose in normal islet non β-cells may obscure stimulation of PC2 biosynthesis in normal islet β-cells.
【 授权许可】
Unknown
【 预 览 】
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RO201912020300448ZK.pdf | 494KB | download |