Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa

FEBS Letters

Jones, S.E.¹  Neal, M.J.¹  Jomary, C.¹ 

[1] British Retinitis Pigmentosa Society Laboratory, Department of Pharmacology, The Rayne Institute, UMDS, Guy's and St. Thomas' Hospitals, London, SE1 7EH, UK

关键词: Retinitis pigmentosa;    Retina;    Tissue inhibitor of metalloproteinase;    Extracellular matrix;    Gene expression;    Apoptosis;   

DOI  :  10.1016/0014-5793(94)00951-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To explore the molecular and cellular mechanisms associated with photoreceptor death in retinitis pigmentosa (RP), we have investigated altered transcriptional activity in RP retinas by a differential cDNA screening approach. We identified a clone (K222) showing over-expression in simplex RP retinas compared with controls. K222 encodes a partial cDNA of the human tissue inhibitor of metalloproteinases-3 (TIMP3) gene, a member of a family of genes implicated in extracellular matrix (ECM) remodelling. Increased expression of TIMP3 in degenerating RP retinas may reflect restructuring of the ECM architecture, and disruption of photoreceptor—matrix interactions could contribute to activation of apoptotic cell death processes.

【 授权许可】

Unknown