Nicotinamide, a missing link in the early stress response in eukaryotic cells: A hypothesis with special reference to oxidative stress in plants

FEBS Letters

Berglund, Torkel¹ 

[1] Department of Biochemistry and Biotechnology, Royal Institute of Technology, S-100 44 Stockholm, Sweden

关键词: DNA methylation;    Nicotinamide;    Oxidative stress;    Plant defense metabolism;    Poly(ADP-ribose)polymerase;    Trigonelline;    CHS;    chalcone synthase;    GSH;    reduced glutathione;    GSSG;    oxidized glutathione;    NIC;    nicotinamide;    PADPRP;    poly(ADP-ribose)polymerase;    PAL;    phenylalanine ammonia-lyase;    SAM;    S-adenosyl-nethionine;    TRIG;    trigonelline;   

DOI  :  10.1016/0014-5793(94)00850-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A hypothesis is presented suggesting that nicotinamide (NIC) is an initial signal substance in the response of eukaryotic cells to conditions which cause DNA-strand breakage, especially in connection with oxidative stress. In the stressed cell, NIC is released as a result of the activity of poly(ADP-ribose)polymerase (PADPRP). PADPRP is known to be activated by DNA-strand breakage, caused by e.g. oxidative stress or mutagens. NIC and its metabolite trigonelline (N-methylnicotinic acid) can induce defensive metabolism at the gene level. Connections between NIC and DNA-methylation are also considered. This hypothesis is discussed in the light of own observations and literature reports.

【 授权许可】

Unknown