Molecular cloning of the human type VIII adenylyl cyclase

FEBS Letters

Hanoune, Jacques¹  Defer, Nicole¹  Matsuoka, Isao¹  Danisova, Alena¹  Marinx, Olivier²  Caput, Daniel²  Iourgenko, Vadim¹  Stengel, Dominique¹ 

[1] U-99 INSERM, Hopital Henri Mondor, F-94010 Creteil, France;Sanofi Recherche, Labège Innopole, 31676 Labège cedex, France

关键词: Adenylyl cyclase;    Human brain;    cDNA cloning;    Amino acid sequence;   

DOI  :  10.1016/0014-5793(94)00836-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA coding for a human type VIII adenylyl cyclase has been isolated from human newborn brain-stem tissue. This cDNA is 6,005 bp long and encodes for a protein of 1251 amino acids, exhibiting the two sets of six transmembrane spanning regions and the hydrophobicity profile typical of other mammalian adenylyl cyclases. Comparison with the rat form shows that they share 97% identity in amino acids. Type VIII adenylyl cyclase is unique in that it has both a long carboxy terminal and a long amino terminal tail. This is the first report on a complete cDNA clone coding for a human adenylyl cyclase. The distribution and regulation of this particular adenylyl cyclase suggest that it may be involved in learning, in memory and in drug dependence.

【 授权许可】

Unknown