Effect of aging and acetyl‐l‐carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria

FEBS Letters

Gadaleta, Maria Nicola¹  Paradies, Giuseppe¹  Quagliariello, Ernesto¹  Petrosillo, Giuseppe¹  Ruggiero, Francesca Maria¹ 

[1] Department of Biochemistry and Molecular Biology and C.N.R. Unit for the Study of Mitochondria and Bioenergetics, University of Bari, Bari, Italy

关键词: Cytochrome oxidase;    ADP translocase;    Aging;    Acetyl-l-carnitine;    Rat heart mitochondria;    Ac. Carn.;    Acetyl-l-carnitine;    CAT;    carboxyatractyloside;    TMPD;    N;    N;    N′N-tetramethyl-p-phenylenediamine;   

DOI  :  10.1016/0014-5793(94)00763-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of aging and treatment with acetyl-l-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria was studied. It was found that the activity of both these mitochondrial protein systems was reduced (by around 30%) in aged animals. Treatment of aged rats with acetyl-l-carnitine almost completely reversed this effect. Changes in the mitochondrial cardiolipin content appear to be responsible for these effects of acetyl-l-carnitine.

【 授权许可】

Unknown