Bacterial protein toxins penetrate cells via a four‐step mechanism

FEBS Letters

Montecucco, Cesare¹  Papini, Emanuele¹  Schiavo, Giampietro¹ 

[1] Centro CNR Biomembrane e Dipartimento di Scienze Biomediche, Università di Padova, Via Trieste 75, 35121 Padova, Italy

关键词: Bacterial toxin;    Mechanism;    Internalization;    Membrane translocation;    Target;    BoNT;    botulinum neurotoxin;    CLT;    cholera toxin;    DT;    diphtheria toxin;    EF;    anthrax edema factor;    LT;    heat-labile E. coli toxin;    PT;    pertussis toxin;    ST;    Shiga toxin;    TeNT;    tetanus neurotoxin;   

DOI  :  10.1016/0014-5793(94)00449-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Bacteria produce several protein toxins that act inside cells. These toxins bind with high affinity to glycolipid or glycoprotein receptors present on the cell surface. Binding is followed by endocytosis and intracellular trafficking inside vesicles. Different toxins enter different intracellular routes, but have the common remarkable property of being able to translocate their catalytic subunit across a membrane into the cytosol. Here, a toxin modifies a specific target with ensuing cell alterations, necessary for the survival and diffusion strategies of the toxin producing bacterium.

【 授权许可】

Unknown