Copper pumping ATPases: Common concepts in bacteria and man

FEBS Letters

Krapf, Reto¹  Odermatt, Alex¹  Solioz, Marc¹ 

[1]Department of Clinical Pharmacology, University of Berne, Murtenstrasse 35, 3010 Berne, Switzerland

关键词: Copper;    ATPase;    Transport;    Menkes disease;    Wilson disease;    Enterococcus hirae;   

DOI  :  10.1016/0014-5793(94)00316-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recently, four genes encoding putative copper pumping ATPases have been cloned from widely different sources: two genes from Enterococcus hirae that are involved in copper metabolism and two human genes that are defective in the copper-related Wilson and Menkes disease. The predicted gene products are P-type ATPases. They exhibit extensive sequence similarity and appear to be members of a new class of ATP driven copper pumps involved in the regulation of cellular copper.

【 授权许可】

Unknown