期刊论文详细信息
FEBS Letters | |
The 3D structure of a cyclosporin analogue in water is nearly identical to the cyclophilin‐bound cyclosporin conformation | |
Walliser, Louis1  Wenger, Roland M.1  Bovermann, Günter1  Widmer, Hans1  France, Julien1  Widmer, Armin1  | |
[1] Preclinical Research, Sandoz Pharma AG, CH-4002 Basel, Switzerland | |
关键词: Cyclosporin; Cyclophilin; Affinity; Conformation in water; CS; cyclosporin A; CYP; cyclophilin A; NOE; nuclear Overhauser effect; RMSD; root mean square deviation; | |
DOI : 10.1016/0014-5793(94)80149-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The conformation of [d-MeSer3-d-Ser-(O-Gly8]CS, a water soluble cyclosporin derivative, has been determined in (D6)DMSO and in water using NMR. In these polar solvents the conformation is identical and very similar to the structure found in the cyclophilin-cyclosporin complex. However, it differs significantly from its conformation in deuterated chloroform. This demonstrates unambiguously that the large structure change is induced primarily by the polar solvent rather than by complex formation with cyclophilin.
【 授权许可】
Unknown
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