Succinic acid monomethyl ester protects rat pancreatic islet secretory potential against interleukin‐1β (IL‐1β) without affecting glutamate decarboxylase expression or nitric oxide production

FEBS Letters

Niemann, Audrey³  Welsh, Nils³  Velloso, Licio A.¹  Malaisse, Willy J.²  Eizirik, Décio L.³ 

[1] Department of Internal Medicine, Uppsala University, Uppsala, Sweden;Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium;Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

关键词: Interleukin-1β;    Succinate ester;    Nitric oxide;    Pancreatic islet;    Glutamic acid decarboxylase;    Aconitase;    Diabetes mellitus;   

DOI  :  10.1016/0014-5793(94)80213-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rat pancreatic islets exposed to interleukin-1β (IL-1β) in the presence of succinic acid monomethyl ester (SAM) have a higher insulin release in response to glucose and higher glucose oxidation rates, as compared to islets exposed to IL-1β alone. These beneficial effects of SAM were not accompanied by any decrease in IL-1β-induced nitric oxide (NO) production nor inhibition of aconitase activity. Moreover, SAM did not increase biosynthesis of glutamate decarboxylase. SAM apparently improves β-cell function mostly by increasing the capacity of these cells to endure NO exposure and partial blockage of the Krebs cycle.

【 授权许可】

Unknown