Brefeldin A blocks protein glycosylation and RNA replication of vesicular stomatitis virus

FEBS Letters

Pérez, Luis¹  Carrasco, Luis¹  Irurzun, Alicia¹ 

[1] Centro de Biología Molecular, Universidad Autónoma de Madrid, Canto Blanco, 28049 Madrid, Spain

关键词: Brefeldin A;    Vesicular stomatitis virus;    RNA replication;    Protein glycosylation;   

DOI  :  10.1016/0014-5793(93)80863-P

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Brefeldin A is a macrolide antibiotic that interferes with membrane traffic and blocks the growth of several animal viruses including vesicular stomatitis virus (VSV). The inhibition of VSV by brefeldin A takes place at least at two different steps during the growth cycle: the glycosylation of VSV G protein and the replication of viral genomes. Our results indicate that interference with membrane traffic leads not only to inhibition of viral protein glycosylation, but also to the blockade of virus genome replication in several cytoplasmic RNA-containing viruses.

【 授权许可】

Unknown