Megalomycin C, a macrolide antibiotic that blocks protein glycosylation and shows antiviral activity

FEBS Letters

Alarcón, Balbino¹  Carrasco, Luis¹  González, M.Eugenia¹ 

[1] Departamento de Microbiología, Centro de Biología Molecular, Universidad Autónoma, Cantoblanco, 28049 Madrid, Spain

关键词: Megalomycin C;    Protein glycosylation;    Antiviral activity;   

DOI  :  10.1016/0014-5793(88)80732-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Megalomycin C, a natural macrolide antibiotic showed a potent antiherpetic activity. At concentrations that efficiently prevented HSV-1 multiplication, the compound had no cytotoxic or antiproliferative effects. Viral DNA and protein synthesis took place at normal levels in the presence of the antibiotic, suggesting that neither the translation of viral mRNA, nor the synthesis of viral nucleic acids was affected. The incorporation of mannose and galactosamine into viral proteins was blocked and precursor, but not mature, HSV-1 glycoproteins were detected in the presence of megalomycin C. Noninfectious HSV-1 viral particles were formed when the compound was present, but their glycoproteins were not properly glycosylated.

【 授权许可】

Unknown